Med. Weter. 68 (12), 707-711, 2012

full text

Larski Z.
Some new data concerning virology, prions and immunology
Discovery of a canine homolog of hepatitis C virus provides the exciting prospect of a unique experimental model for HCV infections in humans. Interferon-inducible transmembrane 3 protein acts as an essantial barier to influenza A virus infection in vivo and in vitro. Lymphoid tissue is consistently more permissive than the brain to prions such as those causing chronic wasting disease of deer and elk, and bovine spongiform encephalopathy. Population of innate response activator (IRA) B cells protects against septic shock by controlling the organism’s ability to clear bacteria. Exposure to commensal microbes during early childhood is critical for later enviromental exposures and protects from immune-mediated diseases such as inflammatory bowel disease and astma. Langerhans cells can enhance chemical carcinogenesis via metabolism of polyaromatic hydrocarbons. Attempts to prevent Alzheimer’s disease by using antibodies
Key words: canine homolog of HCV, influenza, prions, sepsis, astma, Langerhans cells, Alzheimer’s disease