Med. Weter. 80 (11), 590-594, 2024
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| SEZAI ARSLAN, SEVDA INAN |
| The effect of experimentally induced acute fluoride poisoning on the thyroid gland and hormones in geriatric rats. |
| The aim of this study was to investigate the effects of fluoride on the thyroid gland and hormones in rats with acute poisoning by different doses of fluoride. For this purpose, a total of 5 groups were formed, including a control (C) group of 8 rats and 4 test groups consisting of 10 rats each. Toxicity was induced with NaF at doses of 45, 60, 70, and 90 mg/kg/bw in the test groups F45, F60, F70, and F90, respectively. During the study, 2 rats died in F45, 3 in both F60 and F70, and 4 in F90. Surviving rats were euthanized 24 hours after poisoning, and blood samples were collected. Urine samples were also taken before and after poisoning. Urinary fluoride levels increased after intoxication and were found to be statistically significant. There were no significant differences in the levels of thyroid hormones TT3, TT4, and FT4 between the test groups and the control group. However, a significant decrease in FT3 levels was observed in the test groups compared to the control group. Although there were no significant changes in TSH hormone levels in the F45 and F90 groups compared to the control group, a significant decrease was observed in the F60 and F70 groups. Histopathological examination revealed follicular degeneration, a decrease in the volume of colloidal fluid, and atypical follicular epithelium in the thyroid glands of the test groups. In conclusion, abnormal changes in the thyroid gland and hormones were observed in rats with acute poisoning by different doses of fluoride. |
| Keywords: acute, flüoride poisoning, thyroid, geriatric rat |