Med. Weter. 79 (4), 182-185, 2023

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MICHALINA ADASZYŃSKA-SKWIRZYŃSKA , SŁAWOMIR ZYCH, DANUTA SZCZERBIŃSKA
In vitro antibacterial effect of enrofloxacin combined with lavender essential oil on selected Salmonella serotypes isolated most commonly poultry
The present study investigated the antimicrobial activity of enrofloxacin in combination with lavender (Lavandula angustifolia) essential oil against three serotypes of Salmonella: Salmonella Enteritidis ATCC 13076, Salmonella Gallinarum biovar Pullorum ATCC 13036, Salmonella Typhimurium ATCC 14028 and Salmonella Typhimurium – a moderately sensitive monophasic strain. The analysis of the interaction of enrofloxacin with lavender essential oil was carried out using the checkerboard method. The obtained FICI values were interpreted as follows: synergistic when ≤ 0.5; additive when > 0.5 but ≤ 1; non-interactive when > 1 but ≤ 4; antagonistic when > 4. When analysing individual combinations of enrofloxacin with lavender oil, a positive additive effect was found in all cases (S. Enteritidis ATCC 13076 FICI – 0.85; S. Gallinarum biovar Pullorum ATCC 13036 FICI – 1.0; S. Typhimurium ATCC 14028 and S. Typhimurium – a moderately sensitive monophasic strain FICI – 0.7). Antagonistic interaction was not recorded in any case. When analysing individual combinations of enrofloxacin with lavender oil against the serotypes tested, an additive effect was demonstrated in all cases (FIC indices: 0.7-1.0). There was no antagonistic effect in any of the analysed combinations.
Keywords: lavender essential oil, enrofloxacin, antibacterial activity