Medycyna Wet. 62 (2), 223-226, 2006
Pomianowski A., Kuleta Z., Sobiech P., Wiśœniewska M., Procajło A.
Effects of acetazolamide on acid-base and electrolyte equilibrium parameters and electrocardiograms in dogs
The aim of study was estimate the effects of acetazolamid administration on arterial acid-base equilibrium and electrolyte concentrations and electrocardiograms in dogs. The study was carried out on 10 mixed-breed dogs, which were administered acetazolamid over 3 days in doses of 30 mg/kg b.w. twice a day. Administration of acetazolamid caused a decrease in pH levels, partial pressure of carbon oxide, bicarbonates in the blood and ions of potassium in the serum. An increase of chloride and sodium concentration in serum was also observed. These results indicate hypochloremic metabolic acidosis associated with hypokalemia. Electrocardiography recordings in the examined dogs were abnormal. Prolonged QT intervals, depression of ST segments and the appearance of a paroxysmal, polymorphous type of ventricular tachycardia were also recorded.
Keywords: dogs, acetazolamide