Medycyna Wet. 62 (3), 254-256, 2006
Glińska K., Nicpoń J., Pawlas M.
Mechanism of action statins and possibilities of their application in dog therapy
Statins are inhibitors of the 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA) of the key enzyme in cholesterol biosynthesis. Numerous studies on their effectiveness have demonstrated that statins reduce the total cholesterol and low density lipoprotein (LDL) concentration. The application of statins could be useful in the therapeutic management in hyperlipidemias in which dietary therapy does not bring expected results, as well as for primary hyperlipidemia in dogs and lipid metabolism disorders resulting from other diseases like diabetes.
Keywords: dog, statins, hyperlipidemia