Medycyna Wet. 62 (7), 797-800, 2006
Zań R., Kowalski C., Burmańczuk A.
Validation method for determination of 8-a-hydroxymutilin in biological material
A validation method is a key element in both the elaboration of reference methods and the assessment of a laboratory's competence in producing reliable analytical data. The aim of the study was to validate the GC method (according to Marcus and Sherma), which is used in determining 8-a-hydroxymutilin in a biological matrix (swine tissues: liver and muscles). The fundamental parameters for validation, including accuracy, precision, selectivity, sensivity, reproductibility and stability, were estimated. The studies confirmed the usefulness of the GC method for determining tiamulin residues in swine tissues.
Keywords: 8-α-hydroxymutilin, tiamulin, pigs