Medycyna Wet. 62 (6), 686-689, 2006
| Grochowina B., Janus K. |
| Pharmacokinetics of paracetamol in calf plasma and saliva |
| The aim of the investigation was the pharmacokinetics of paracetamol (as a model drug) in plasma and saliva in calves at different ages. The experiment was carried out on 15 healthy calves of BW (Black-and- -White) breed. Paracetamol (5 mg/kg bw.) was administered per os on the tenth, twentieth and fourteenth days of the calves lives. The concentration of the model drug in the plasma was determined by the spectrophotometric method. Pharmacokinetic parameters were estimated using a non-compartmental method by means of the TopFit computer program. It was determined that paracetamol concentration in the plasma and saliva was significantly different in many analyzed time points. Insignificant differences were observed in 10-day-old calves after 1.5, 2 and 3 hours after drug administration. In 20 and 40-day-old calves, insignificant changes were observed after 2 and 3 hours after paracetamol administrations. In all examined animals maximal paracetamol concentration was observed after 1 hour following drug administration. The obtained results indicate that saliva is not a good biological fluid for the determination the paracetamol pharmacokinetic parameters in calves. |
| Keywords: paracetamol, pharmacokinetics, plasma, saliva |