Medycyna Wet. 62 (6), 683-685, 2006
| Lutnicki K., Szpringer E., Marciniak A. |
| Ethanol evoked oxidation-antioxidation imbalance in rats |
| Ethanol administration is able to induce oxidative stress, resulting in the activation of defense mechanisms, but sometimes ROF production is very intensive and disturbs the balance between its generation and antioxidant capacity. The obtained results show that concentrations of CD, HPETE and MDA in plasma after 2hr, 12hr and 24hr pos-ethanol administration were significantly higher than in the control group of animals. 50% ethanol administered orally resulted in a significant increase of lipid peroxide levels in plasma with a simultaneous increase in SOD activity throughout the entire 24 hr period of the experiment. Gpx activity was significantly higher during the first 2 hrs following ethanol administration and then decreased to become lower than in the control group at 12 and 24 hrs. TAS in plasma decreased at hr12 and hr24 following ethanol exposure. Ethanol ingestion disturbed the plasma antioxidant system and augmented lipid peroxidation in a time dependent manner. The increased MDA production was strong evidence that lipid peroxidation is the one of main mechanisms of alcoholic tissue damage. |
| Keywords: ethanol, lipid peroxidation, antioxidant system |