Medycyna Wet. 62 (11), 1276-1280, 2006
Glińska K., Hałoń A., Pasławska U., Noszczyk-Nowak A., Nicpoń J., Rabczyński J.
Histopathological changes in the liver in right side heart failure in dogs
Right side heart failure occurs in dogs less frequently than left side heart failure. It causes serious hemodynamic sequelae in the form of peripheral stasis with transudates to body cavities, as well as causing stasis edema of parenchymal organs and their defective functioning. The study material included 10 dogs subjected to euthanasia due to clinical signs of the end-stage of right side heart failure. The animals underwent morphological and biochemical blood tests as well as heart and abdominal USG. Autopsies were carried out and liver samples were collected for histopathological assessment. The preparations were stained by the following methods: hematoxyline-eosine (HE), Van Gieson and Mallory. All the examined dogs manifested typical symptoms of right side heart failure in the form of ascites, quick fatigue and the loss of appetite. Most dogs demonstrated blue mucous membranes and mixed dispnea. The blood tests indicated an increase in leucocytes, GOT, GPT, FA, GGT, total bilirubin and urea levels. In the histopathological examination of liver samples, passive hyperemia and Disse spaces were found in all the cases. Lipid liver parenchyma degeneration was found in 90% of the examined specimens. Fibrosis in portal spaces was detected in 40% of the animals. Summing up, it can be stated that in the histopathological picture of the livers the dominant lesions caused by right side heart failure were lipidosis and passive hyperemia of the organ. This was reflected in the laboratory results of the examined blood serum liver profile parameters indicating inconsiderable liver function disorders.
Keywords: dog, heart failure, liver