Medycyna Wet. 63 (6), 635-637, 2007
Chrostowska M., Jaroszewski J., Markiewicz W.
Effects of non-steroidal anti-inflammatory drugs on corpus luteum function
Non-steroidal anti-inflammatory drugs (NSAIDs) are the most widely used drugs in both human and veterinary medicine. NSAIDs inhibit the enzyme cyclooxygenase in the arachidonic acid cascade. This mechanism results in a reduced or blocked synthesis of prostaglandins. Eicosanoids are very important for reproduction and their inhibition by NSAIDs may cause disorders in the ovarian cycle. The article summarizes the latest knowledge about the effects of NSAIDs on corpus luteum function.
Keywords: corpus luteum, prostaglandins, non-steroidal drugs