Medycyna Wet. 63 (9), 1084-1089, 2007
| Witek B., Ochwanowska E., Stanisławska I., Wróbel A., Mierzwa W., Kołątaj A., Bagnicka E. |
| Effect of testosterone on the activity of lysosomal enzymes in the mouse liver and kidney maintained on the different protein level in diet |
| The experiment was conducted on the influence of testosterone on the activity of ten lysosomal enzymes in the mouse liver and kidney. Mice were divided into two feeding group [control 16% protein] and [10% protein] in diet. The animals of the both groups were injected with 0.05 mg/kg b.w. of testosterone intraperitoneally. In the lysosomal fraction of the liver and kidney the activity of lysosomal enzymes were estimated. Testosterone decreased activity of all investigated enzymes in the liver, except alanine aminopeptidase, cathepsins D and L, lysosomal lipase. In the lysosomal fraction of the kidney testosterone decreased of all lysosomal enzymes, too, except alanine aminopeptidase. The results suggest that exogenous testosterone and different proteins diet had a significant influence on the activity of investigated lysosomal enzymes. |
| Keywords: testosterone, protein diet, lysosomal enzymes, mice |