Medycyna Wet. 64 (7), 883-885, 2008
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| Tamaddonfard E., Tajik H., Hamzeh-Gooshchi N. |
| Effects of curcumin and vitamin C on visceral nociception induced by acetic acid in rats |
| The present study investigates the effects of 14 days oral administration of curcumin and 7 days intraperitoneal injection of vitamin C in separate and combined treatments on visceral nociception in rats. Visceral nociceptive responses including the latency time to the beginning of the first abdominal wall contraction (first writhe) and the number of writhes were recorded for a period of 1 h after an intraperitoneal injection of acetic acid (1 cm3, 2%). In chronic separate treatments with curcumin and vitamin C at the same doses of 12.5 and 25 mg/kg B.W., nociceptive responses were significantly (p < 0.05) attenuated. In chronic combined treatments with curcumin and vitamin C at the same dose of 12.5 mg/kg B.W., the suppression of pain was significantly (p < 0.05) greater than the one obtained with the same dose of 12.5 mg/kg B.W. of both agents used separately. Based on the results of this study, it is concluded that both curcumin and vitamin C are able to suppress visceral pain, and vitamin C may potentiate the antinociception induced by curcumin. |
| Keywords: curcumin, vitamin C, visceral nociception, rats |