Medycyna Wet. 65 (1), 29-32, 2009
Ćwiek A., Balicki I., Różańska D., Polkowska I., Orzelski M..
Propofol-induced inhalation anaesthesia in dogs after xylasine or xylasine and midazolam premedication.
The objective of the studies was to compare the premedication with xylasine alone and a midazolam/xylasine combination applied for inhalation anaesthesia induction with propofol. The studies aimed at determining the effect of the examined anaesthesia methods on the animals’ physical condition, the acid-base balance parameters and arterial blood oxygenation. The study was conducted on 48 male mixed-breed dogs aged from 3 to 11 years, of 5-25 kg body weight. The animals were divided into two groups. Group I was premedicated with xylasine (2 mg/kg bw.) and atropine (0.05 mg/kg bw.) intramuscularly, and group II was administered xylasine (1 mg/kg bw.), atropine (0.05 mg/kg bw.) and midazolam (0.2 mg/kg bw.) intramuscularly. In both groups the premedication was followed after 20 minutes with propofol used for induction, given to effect intravenously. General anaesthesia was conducted by administering a mixture of halothane and oxygen. Propofol was shown to induce loss of consciousness in the animals premedicated with xylasine alone or a xylasine/ midazolam combination at the mean dose of 3.12 and 3.13 mg/kg bw. respectively. Premedication with singleagent xylasine or xylasine in a twofold lower dose in conjunction with midazolam does not affect the propofol dose required to induce unconsciousness. The administration of midazolam/xylasine preanaesthetics compared to the premedication with xylasine alone suppresses vomiting as well as accelerates the recovery and return of motor functions in patients anaesthetised with propofol.
Keywords: dog, xylasine, midazolam, propofol, induction