Medycyna Wet. 67 (3), 172-176, 2011
| Maślanka T. |
| Current opinions on regulatory cells in cattle, pigs and dogs |
| Regulatory T cells are responsible for the regulation of immune response and play a leading role in developing immune tolerance through active suppression. These cells are relatively well characterized in mice and humans: they are a heterogeneous population of lymphocytes including CD4+CD25+Foxp3 (Treg), Tr1, Th3, γδ T and NK cells, as well as CD8+ regulatory lymphocytes, i.e., CD8+CD25+Foxp3+, CD8+Foxp3+, CD8+CD122+ and CD8+CD28- cells. Unfortunately, our current state of knowledge about regulatory cells in cattle, pigs, dogs and other domestic animals is relatively poor. In recent years, however, some progress has been achieved in this field. It has been demonstrated that in bovines the regulatory function appears to reside in γδ T cells, whereas conflicting results have been reported regarding the regulatory properties of CD4+CD25+ cells. CD4+CD25high cells have been identified as regulatory cells in pigs, although CD4+CD25low lymphocytes also seem to have some regulatory properties in this species. CD4+CD25highFoxp3+ and CD4+CD25lowFoxp3+ induced cells have been demonstrated in canine blood. However, in dogs the suppressor activity has been evaluated and confirmed only for their CD25+ lymphocytes. This paper summarizes the current state of knowledge concerning the regulatory cells in cattle, pigs and dogs. |
| Keywords: regulatory cells, CD4, CD25, cattle, pig, dog. |