Med. Weter. 68 (6), 349-352, 2012

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Pasławska U., Kurzok H., Kiczak L., Bania J.
Role of nitric oxide in the regulation of the cardiovascular function
Nitric oxide (NO, earlier known as EDFR - Endothelium-Derived Relaxing Factor) is a multifunctional particle involved in physiological as well as pathological reactions. The specificity of these reactions depends on the NO concentration, location and interactions with other particles. Nitric oxide affects the dilatation of blood vessels and immunological reaction. It influences cardiovascular myocyte tonus (contraction) and counteracts vasoconstrictive factors such as endothelin-1 and angiotensin-II, thereby ensuring proper tissue perfusion depending on current requirements. NO protects vessel walls by preventing lipid peroxidation and decreasing the activity of reactive oxygen radicals. Nitric oxide shows anticoagulant properties by inhibiting the adhesion, activation and aggregation of trombocytes.
Key words: nitric oxide, heart, cardio-vascular