Med. Weter. 69 (6), 333-340, 2013

full text

pdf
Madej J.A., Madej J.P., Kandefer-Gola M.
Inflammatory process in immune-privileged organs
Organs in which inflammation goes by different rules through protecting them against damage are called immunologically privileged. These include the central nervous system, the front chamber of the eye (excluding the cornea), the liver, the kernel, the pregnant uterus, hamster cheek pouches and hyaline cartilage. The brain immunological privilege is due to fact that it has no lymphatic vessels and contains a small number of T-lymphocytes and macrophages, while a blood-brain barrier is present. In the brain, there is a long-term graft survival of allo-and xenografts, such as the adrenal medulla tissue or fetal tissue allografts. The anterior chamber of the eye is also an immunologically privileged area, which is often a convenient place for grafts of experimental tumors in animals. Inside the testes tolerance of autoantigens present in the germ cells is attained, which is maintained by the presence of incomplete barriers limiting access to reproductive cell antigens of immune cells and antibodies. In other parts of the body such a response to an antigen is not found, which makes these organs very interesting from the point of view of pathogenesis and immunity.
Key words: immune privileged organ, allograft, inflammation, blood – brain barrier, lymphocyte