Med. Weter. 71 (4), 198-205, 2015

full text

Fitzner A.
Vesicular stomatitis and its causative agent: The risks and perspectives
Vesicular stomatitis (VS) is a viral disease of horses, cattle and swine caused by vesiculoviruses (VSV) of the Rhabdoviridae family. The disease is a zoonosis. VS is endemic in the Western Hemisphere, where its incidence is confined to the warmer regions of North America, as well as Central and South America with tropical climate. The article presents the most important issues concerning the historical background and current status of the disease and its etiological agent. The impact of climatic and ecological conditions on the emergence of new outbreaks and virus strain evolution is discussed, as well as the role of insects in the epidemiology of infections and limited possibilities of specific prevention. The importance of VS virus as a vaccine and oncolytic vector and prospects for its use in the prevention of human infectious diseases and cancer therapy are also highlighted.
Key words: Vesicular stomatitis, vesicular stomatitis virus, virotherapy