Med. Weter. 72 (1), 41-45, 2016
full text
| Kempisty B., Zaorska K., Bukowska D., Ciesiółka S., Wojtanowicz-Markiewicz K., Nowak M., Antosik P., Gehrke M., Brüssow K.-P., Bruska M., Nowicki M., Zabel M. |
| TP53 gene polymorphisms with mammary gland tumors and aging in bitches |
| Blood samples were collected from 22 bitches with diagnosed mammary gland malignant tumors, according to the WHO’s International Classification of Disease for Oncology System. The control group (n = 35) consisted of geriatric (> 5 to 10 years old), mature (2-5) and young (1-2) females. We found two novel single nucleotide variants in the coding region of exon 3 and in intron 7 of gene TP53. We did not observe statistical significance in allele or genotype distribution between the tumor and control groups. However, the prevalence of allele C (Odds ratio = 3.0; p = 0.2024) similarly to genotype CT (Odds ratio = 3.3; p = 0.1783) was higher in the control group than in the investigated cancer group. Nonetheless, additional studies on larger groups of canines are required to confirm the presented results. |
| Key words: mammary glands, malignant tumor, bitch, aging, polymorphism TP53 |