Med. Weter. 73 (2), 82-87, 2017

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Artur Bryja, Marta Dyszkiewicz-Konwińska, Joanna Budna, Wiesława Kranc, Adrian Chachuła, Sylwia Ciesiółka, Ewa Sumelka, Mateusz Krajecki, Dorota Bukowska, Paweł Antosik, Michał Nowicki, Małgorzata Bruska, Bartosz Kempisty
Carcinogenesis in mammalian oral mucosa from the perspective of biomedical research
Neoplastic diseases are a challenge to modern medicine. The understanding of histological, molecular and genetic transformation leading to cancer is essential in establishing methods for earlier diagnosis and better treatment of oral cavity cancer, not only in humans but also in animals – in particular, in dogs and cats, which develop oral cancer spontaneously. There are several methods of cancer modeling that expand research capabilities. The following overview discusses different methods of inducing carcinogenesis in animals and presents animal models used in the study of carcinogenesis. Publications reviewed in the paper discuss markers used in the diagnosis of oral cancer and describe the concept of cancer stem cells.
Key words: carcinogenesis, HNSCC, OSCC, cancer stem cell