Med. Weter. 2018, 74 (9), 581-586

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Comparative study of midazolam-propofol and metamizole-propofol clinical effects in domestic pigeons
This study was conducted to determine the quality of anesthesia by evaluating the clinical effects of midazolam-propofol and metamizole-propofol on domestic pigeons. The aim of the study was to choose an appropriate injectable anesthetic protocol by utilizing midazolam and metamizole as pre-anesthetic drugs in order to reduce the dose of propofol and decrease side effects. Eighteen male pigeons weighing 304.2±32.3g (mean±SD) were randomly allocated to three groups of six pigeons each. Midazolam (6 mg/kg/IM) and metamizole (500 mg/kg/IM) were used five minutes prior to administration of propofol (8 mg/kg/IV) in groups I and II, respectively, while the birds in group III (control group) received metamizole (500 mg/kg/IM). Five minutes after the last injection, clinical parameters of various systems were evaluated. Nervous system parameters declined in groups I and II, while reflexes could still be elicited in group III (P<0.05). There were no significant changes in the heart rate, dysrhythmia, or gastrointestinal parameters in the three groups (P>0.05). The birds in group II showed reduced jaw and limb muscle tone (P<0.05). Corneal and palpebral reflexes were absent in groups I and II (P<0.05). Both respiratory depth and pattern were irregular in group I, while all the parameters were normal in group II (P<0.05). The respiratory rate decreased in all groups after injection, although this reduction was significant only in group I (P<0.05). In conclusion, the combination of metamizole-propofol is safer and more compatible with the physiology of pigeons and can be used for short operations, especially when inhalation agents are contraindicated..
Key words: anesthesia, metamizole, midazolam, propofol, pigeon