Med. Weter. 2020, 76 (9), 525-528

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Utility of urinary markers in the assessment of renal dysfunction in dogs with chronic kidney disease
Chronic kidney disease is a common and clinically significant disease. This complication leads to a decrease of the glomerular filtration rate and in consequence causes azotaemia and uraemia. The objective of this study was to assess the localization and extent of renal damage in dogs with stage-3 chronic kidney disease using a urinary marker for glomerular dysfunction, proximal tubular dysfunction and distal tubular dysfunction (uIgG, uRBP and uTHP, respectively). The examination was performed in twelve dogs affected in stage-3 chronic kidney disease and ten clinically healthy dogs (female and male of comparable age). The levels of urinary biomarkers were measured by commercially available ELISA-tests. In the infected animals a significant renal excretion of HMW protein uIgG and LMW protein uRBP was observed, indicating a dysfunction of the glomerular and tubular regions of the kidneys. Lower levels of uTHP in dogs with CKD was noticed, which may suggest impaired distal tubular regions of the kidneys.
Keywords: chronic kidney disease, urinary marker, immunoglobulin G, retinol binding protein, uromodulin