Medycyna Wet. 66 (10), 716-720, 2010
| Noszczyk-Nowak A., Nowak M., Pas³awska U. |
| Injury to a canine liver induced by long-term oral administration of amiodarone. A case report |
| Amiodarone is an antiarrhythmic drug commonly used in veterinary and human medicine. In humans, a few cases have been described of various degrees of liver pathology in the course of amiodarone treatment. Until now only benign hepatic disturbances have been described in dogs. The authors observed signs of liver damage in a dog after 26 months of treatment with amiodarone: AST (U/l) = 189, ALT (U/l) = 860, proteins (g/l) = 41, albumin (g/l) = 20. After carrying out an autopsy and histopatological examination, inflammatory processes and pronounced degenerative lesions, including fatty degeneration, with a clear reconstruction of hepatic parenchyma and development of cirrhosis were noted. This is the first description of fatal damage of the liver in a dog with arrhythmias, which was treated with amiodarone for 2 years. |
| Key words: dog, amiodaron, damage of liver |