Med. Weter. 69 (4), 235-240, 2013
full text
| Laus M.N., Denoth F., Ciardi M., Giorgetti L., Pucci L., Sacco R., Pastore D., Longo V. |
| Antioxidant-rich food supplement Lisosan G induces reversion of hepatic steatosis |
| Antioxidant activity (AA) of Lisosan G, a food supplement obtained from wheat grains, was evaluated by using the LOX/RNO, ORAC and TEAC methods. Very high AA was found, associated with a high fraction of freely-extractable phytochemicals expected to be readily absorbed in the small intestine and to exert systemic healthy effects. So, a possible beneficial effect of Lisosan G against non-alcoholic hepatic steatosis induced in mice by 90 days of hyperlipidic diet was studied. Feeding Lisosan G to mice with hepatic steatosis caused rapid reversion of liver disorder: just after 7 days the liver resulted free of steatosis, showing triglyceride content and histological properties similar to control group. Contrarily, the switch of hyperlipidic diet towards a standard diet did not rapidly reverse hepatic steatosis, with a recovery observed only after 30 days. Our results shed a first insight on the therapeutic potential of Lisosan G against the hepatic steatosis disorder in animal species. |
| Key words: Antioxidant activity; hepatic steatosis; hyperlipidic diet; Lisosan G; oxidative stress. |