Med. Weter. 71 (11), 690-695, 2015
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| Czyrek A., Banasik J., Basinska K., Kolankowski J., Marędziak M., Janeczek M. |
| Effect of mixture of ethyl esters of polyunsaturated fatty acids from flax, blackcurrant seed, borage and evening primrose oils on animal body weight, proliferation potential and morphology of mesenchymal stem cells |
| Obesity is an increasingly common problem in animals and researchers are seeking new methods for weight control. Supplements based on oils and their derivatives are gaining supporters. Due to the fact that many oils cause weight gain, researchers have begun to pay attention to their derivatives - ethyl esters of polyunsaturated fatty acids. In our study, we tested the influence of ethyl esters from borage on changes in body weight and the proliferation potential of population of mesenchymal stem cells (MSCs). Over a 5-week period, a group of mice was fed with esters. After euthanasia, population of MSCs was isolated. A mixture of ethyl esters of flax, blackcurrant, borage and evening primrose had a different effect on cells. In the experiment, there was no statistically significant decrease in body weight, but a significant effect was observed in the morphology and proliferation rate of mesenchymal stem cells. We also demonstrated the negative effect of the supplement on cultures of bone marrow stem cells, whereas the effects on adipose-derived stem cells decreased the population-doubling time and increased the proliferation rate. |
| Key words: borage, flax, black currant, evening primrose, ethyl esters, oils, mesenchymal stem cells |