Med. Weter. 81
full text
| ALMINA GÜNEŞ, AYNUR ŞİMŞEK, AKIN KOÇHAN, ÖMER FARUK KATANALP, HASAN İÇEN, BESRA ÇAKMAK, LALE ÇİVİ, DAMLA ÇIĞDEM SAYGI |
| Prospective evaluation of oxidative stress and hematologic indices in dogs with systemic inflammatory response syndrome |
| Systemic inflammatory response syndrome (SIRS) is a complex clinical condition associated with systemic inflammation and oxidative stress. This study aimed to assess oxidative stress status and hematological changes in dogs diagnosed with SIRS and to investigate potential relationships between oxidative stress markers and hematological parameters. Dogs diagnosed with SIRS (n = 31; mean age 3.3 years, range 2 months-12 years) and healthy control dogs (n = 9; mean age 4.2 years, range 4 months-10 years) were included in the study. Serum total antioxidant status (TAS) and total oxidant status (TOS) were measured, and complete blood count parameters were evaluated. Serum TAS levels were significantly lower in dogs with SIRS compared to healthy dogs (mean rank: 18.16 vs. 28.56; p = 0.019), whereas serum TOS levels were significantly higher in dogs with SIRS (mean rank: 22.77 vs. 12.67; p = 0.022). Hematological alterations in dogs with SIRS were variable; leukopenia was detected in 35.5% of cases, lymphopenia in 25.8%, and thrombocytosis in 25.8%. Comparison between groups revealed significant differences only in monocyte percentage, which was higher in dogs with SIRS (p = 0.039), and mean corpuscular hemoglobin concentration, which was lower in dogs with SIRS (p = 0.031). Correlation analyses demonstrated weak, non-significant positive associations between TAS and red blood cell count (r = 0.217), hemoglobin concentration (r = 0.304), and hematocrit (r = 0.287), as well as a weak, non-significant negative correlation between TOS and granulocyte count (r = −0.076). These findings suggest that oxidative stress and hematological alterations may occur concurrently in canine SIRS, but are not necessarily directly or linearly related. Repeated and longitudinal evaluation of oxidative stress markers together with hematological parameters may provide further insight into their relationship in dogs with SIRS. |
| Keywords: canine, systemic inflammatory response syndrome, total antioxidant status, total oxidant status |