Med. Weter. 81
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| ÖMER FARUK KATANALP, HASAN İÇEN, AYNUR ŞİMŞEK, REVŞA EVİN CANPOLAT ERKAN, AKIN KOÇHAN, ALMİNA GÜNEŞ |
| Comparison of serum vitamin D concentrations between dogs with atopic dermatitis and healthy dogs: Pilot study |
| Atopic dermatitis (AD) is a genetically predisposed inflammatory and pruritic skin disease that is common in dogs. Vitamin D is involved in the skin’s barrier function, immune response and the production of antimicrobial peptides. However, since vitamin D has immunomodulatory properties, its deficiency can lead to dermatological problems. The aim of the present study was to determine serum vitamin D concentrations in dogs with AD, compare serum vitamin D concentrations in healthy dogs and dogs with AD, and reveal the relationship between clinical scores and serum vitamin D concentrations. Blood and skin scraping samples were taken from dogs diagnosed with AD clinically using Favrot criteria for diagnosis and differential diagnosis. The canine atopic dermatitis extent and severity index (CADESI-4) and the pruritus visual analog scale (pVAS) were measured in dogs diagnosed with AD. In addition, serum vitamin D concentrations were determined in serum samples taken from these dogs. Serum vitamin D concentrations in dogs with AD and healthy dogs were compared by statistical analysis. Although serum vitamin D concentration was higher in dogs with AD compared to the control group, it was not found to be statistically significant (p > 0.05). It is thought that the high serum vitamin D concentrations are due to changes in cytokine levels in the course of AD affecting vitamin D levels. |
| Keywords: atopic dermatitis, canine, 25-hydroxyvitamin D |