Med. Weter. 80 (11), 595-606, 2024
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| ERRATUM The editorial office of the Medycyna Weterynaryjna informs that at the request of Dr. Gökhan Nur, he is being removed from the list of authors of the article that was published in the issue 11/2024 of Medycyna Weterynaryjna: Nur G., Caylak E. Antioxidant and anti-inflammatory effects of Cerium oxide Salvia veneris nanoparticles on acetamiprid-induced renal and hepatic toxicity in rats. Med. Weter. 2024, 80 (11), 595-606. In the current version, the author of the work is Emrah Caylak, http://dx.doi.org/10.21521/ mw.6953 |
| EMRAH CAYLAK |
| Antioxidant and anti-inflammatory effects of cerium oxide Salvia veneris nanoparticles on acetamiprid-induced renal and hepatic toxicity in rats |
| This study investigates the antioxidant/anti-inflammatory activities of S. veneris extract (SvE) and cerium oxide nanoparticles/S. veneris (CeO2-NPs/SvE). The study first analyzed the total polyphenolic, flavonoid, and saponin contents of SvE. The identification of phenolic compounds was determined using High-Performance Liquid Chromatography (HPLC). Next, the study investigated the hepatoprotective and nephroprotective effects of S. veneris on acetamiprid-induced toxicity in rats. The rats were administered acetamiprid orally for two weeks, alone or in combination with SvE and CeO2-NPs/SvE. Our study found an association between acetamiprid-induced toxicity and significant changes in biochemical, histopathological, antioxidant, and anti-inflammatory parameters. The treatment with SvE and CeO2-NPs/SvE resulted in a reduction of malondialdehyde (MDA), TNF-α and IL-6 cytokine levels, while increasing glutathione (GSH) as superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), IL-10 and TGF-β levels. Our study suggests that cerium oxide nanoparticles synthesized from S. veneris using the green synthesis method could be a protective and therapeutic agent against various diseases. |
| Keywords: antioxidant, anti-inflammatory, Salvia veneris, acetamiprid, nephrotoxicity, hepatotoxicity |