Med. Weter. 82 (8), 372-377, 2026
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| BEYZA SUVARIKLI ALAN, ABDULLAH MURAT ALTINSOY, ZUHAL ALKAY, YUNUS EMRE TUNÇİL, ZAFER BULUT, |
| Effect of acrylamide administration on fecal short-chain fatty acids in rats |
| Acrylamide is formed as a result of the Maillard reaction between sugars and proteins at high temperatures during food processing and can impair intestinal permeability. The aim of this study is to investigate the effect of exposure to different doses of acrylamide on short-chain fatty acid (SCFA) levels in Wistar rats. Thus, in the present study, animals were divided into 6 groups of 10 animals each. Examination of SCFA levels at the end of the 15th day showed a statistically significant increase in acetate levels in group 5 and a statistically significant decrease in group 6 compared to the control group. In addition, when propionate and therefore total SCFA levels were examined at the end of the 15th day, a significant decrease was observed in group 6 compared to the control group. At the end of the 15th day, isobutyrate, isovalerate, and total branched-chain fatty acid levels were examined, and a statistically significant increase was observed in group 6 compared to the control group. The decrease in acetic and propionic acid levels at the highest doses, and thus in the total SCFA amount, suggests that acrylamide has negative effects on the intestinal microbiota. Thus, it can be stated that high-dose exposure to acrylamide can damage both intestinal tissues and the intestinal barrier, leading to changes in the intestine-associated metabolites. |
| Keywords: Acrylamide, rat, feces, short-chain fatty acids |