Med. Weter. 82 (10), 488-492, 2026
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| YING LI, HAO XU, XIAOYU WU, HAOYUAN ZHAI, YUE WU, XIN WANG |
| Protective effect of dihydromyricetin against LPS-induced liver and intestinal injury in mice |
| Objective: This study was conducted to examine the protective effects of dihydromyricetin (DHM) against LPS-induced hepatic and intestinal injury in mice. Methods: Mice were divided into control, LPS, and DHM (100, 200, 400 mg/kg) groups. DHM was given by gavage for 14 days before LPS injection. LPS was injected intraperitoneally to establish injury models. Serum biochemical indexes, hepatic antioxidant indicators, and histopathology with semi-quantitative scoring were assessed. Results: LPS increased serum AST, ALT, DAO, and D-lactate, elevated hepatic MDA, decreased T-SOD, GSH-Px, and T-AOC, and caused severe intestinal and hepatic damage. Medium and high doses of DHM reversed the above changes. Conclusion: DHM protects against LPS-induced hepatointestinal injury through intestinal barrier preservation and antioxidant enhancement, suggesting its potential as a natural feed additive. |
| Keywords: Dihydromyricetin; LPS; Liver and intestinal injury; Antioxidant |